标题: Fast Expandable Chitosan-Fibers Cryogel from Ambient Drying for Noncompressible Bleeding Control and In Situ Tissue Regeneration

作者: Qi, LH (Qi, Luhe); Mu, LX (Mu, Lanxin); Guo, XJ (Guo, Xiaojia); Liu, AX (Liu, Anxiong); Chen, CJ (Chen, Chaoji); Ye, QF (Ye, Qifa); Zhong, ZB (Zhong, Zibiao); Shi, XW (Shi, Xiaowen)

来源出版物: ADVANCED FUNCTIONAL MATERIALS DOI: 10.1002/adfm.202212231提前访问日期: MAR 2023

摘要: Hemorrhage control, especially noncompressible wound hemostasis, is a tremendous challenge in military injuries and other traumas worldwide. Here, a cryogelation strategy and subsequent solvent exchange are developed for the hydrogen bond-induced self-assembly of chitosan fibers and the production of fast expandable chitosan cryogel. Importantly, the ambient drying process facilitates the repeatable deformation performance of the shape-memory cryogel with a response time of approximate to 1.7 s. Due to the capillary-like structure of the cryogel and high hydrophilicity, rapid shape recovery is accompanied by 41 times water absorption ability. It is further demonstrated that chitosan cryogel is beneficial for in situ tissue regeneration by taking advantage of the biodegradability and biocompatibility of chitosan. Thus, chitosan cryogels prepared by this simple and benign method should have efficient hemostatic effect on noncompressible bleeding and severe fatal high-pressure hemorrhage.

作者关键词: chitosan; cryogels; expandable hemostat; non-compressible hemorrhage; shape recovery

地址: [Qi, Luhe; Guo, Xiaojia; Chen, Chaoji; Shi, Xiaowen] Wuhan Univ, Hubei Engn Ctr Nat Polymers Based Med Mat, Hubei Biomass Resource Chem & Environm Biotechnol, Sch Resource & Environm Sci,Hubei Int Sci & Techno, Wuhan 430079, Peoples R China.

[Mu, Lanxin; Liu, Anxiong; Ye, Qifa; Zhong, Zibiao] Wuhan Univ, Hubei Clin Res Ctr Nat Polymer Biol Liver, Hubei Engn Ctr Nat Polymer Based Med Mat, Inst Hepatobiliary Dis,Transplant Ctr,Natl Qual Co, Wuhan 430071, Peoples R China.

通讯作者地址: Shi, XW (通讯作者)，Wuhan Univ, Hubei Engn Ctr Nat Polymers Based Med Mat, Hubei Biomass Resource Chem & Environm Biotechnol, Sch Resource & Environm Sci,Hubei Int Sci & Techno, Wuhan 430079, Peoples R China.

Ye, QF; Zhong, ZB (通讯作者)，Wuhan Univ, Hubei Clin Res Ctr Nat Polymer Biol Liver, Hubei Engn Ctr Nat Polymer Based Med Mat, Inst Hepatobiliary Dis,Transplant Ctr,Natl Qual Co, Wuhan 430071, Peoples R China.

电子邮件地址: yqf_china@whu.edu.cn; hizzb@whu.edu.cn;shixw@whu.edu.cn

影响因子：19.924